Sagnier S, Catheline G, Dilharreguy B, et al. – Researchers conducted a prospective study to determine the association between normal-appearing white matter (NAWM) integrity and post-ischemic stroke recovery in four main domains: cognition, mood, gait, and dependency. The study sample consisted of 207 patients (66 ± 13 years old; 67% men; median National Institutes of Health Stroke Scale score: 3; interquartile range: 2–6). Among these patients, ischemic supratentorial stroke was diagnosed based on a 3T brain MRI performed 24 to 72 hours after symptom onset. Findings suggested an association of NAWM fractional anisotropy with the modified Rankin Scale and the cognitive scores in the models including only radiological variables. Overall, NAWM diffusion tensor imaging parameters measured early after an ischemic stroke were found to be independent predictors of functional outcome and may be additional indicators to include in poststroke recovery.