Spadaccini M, Frazzoni L, Vanella G, et al. - Since efficacy of bowel preparation is an important determinant of outcomes of colonoscopy, experts ascertained if approved low-volume polyethylene glycol (PEG) and non-PEG regimens were as effective as high-volume PEG regimens when taken in a split dose. They recognized randomized controlled trials that contrasted low- vs high-volume bowel cleansing regimens, given in a split dose, for colonoscopy, in a systematic review of multiple electronic databases through January 31, 2019. A total of 7,528 people were comprised of an analysis of data from 17 randomized controlled trials. Inadequacy of bowel cleansing within the low- vs high-volume split-dose regimens and there was minimal heterogeneity, they found no significant differences. Finding suggests that based on a systematic review of 17 randomized controlled trials, low-volume, split-dose regimens appear to be as effective as high-volume, split-dose regimens in bowel cleansing and were properly tolerated, with superior compliance.