Vollema EM, Prihadi EA, Ng ACT, et al. - By analyzing a large cohort in this study, researchers evaluated the prognostic implications of renal dysfunction among patients with aortic stenosis (AS) and patients with various grades of AS. They evaluated patients who were diagnosed with various grades of AS by transthoracic echocardiography, and categorized the participants based on renal function by estimated glomerular filtration rate (eGFR). They focused on the occurrence of all-cause mortality (primary endpoint) and aortic valve replacement (AVR). There were 1,178 patients (mean age 70 ± 13 years, 60% male) in total, including 327 (28%) with aortic sclerosis, 86 (7%) with mild AS, 285 (24%) with moderate AS and 480 (41%) with severe AS. A total of 440 (37%) patients had renal dysfunction (eGFR < 60 ml/min/1.73m²). Findings revealed a high prevalence of renal dysfunction in patients with various grades of AS. An independent link of severely impaired renal function (eGFR < 30 ml/min/1.73m²) with all-cause mortality was found after correcting for AS severity and AVR. A link was identified between AVR and improved survival, independent of renal function.