Kryvenko ON, et al. - Researchers explored how often historically graded GS 5 + 3 = 8 cancers retain this grade with contemporary grading recommendations. They included 16 prostate biopsies and 24 radical prostatectomies (RP) between 2005 and 2019 as GS 5 + 3 = 8 were re-reviewed and graded according to contemporary recommendations. An attempt was made to explain the different grading in discrepant cases. After re-review, one (6%) biopsy and 3 (12%) RPs remained GS 5 + 3 = 8 (GG4). It was showed that two (12%) biopsies remained GG4 but were re-graded as GS 3 + 5 = 8 and 1 (4%) RP was reclassified as GS 4 + 4 = 8 (GG4), eight (50%) biopsies and 15 (64%) RPs were upgraded to Gleason scores 9–10 (GG5), five (32%) biopsies and 1 (4%) RPs were downgraded to Gleason score 7 (GG2 and 3), one (4%) RP indicated GS 3 + 3 = 6 (GG1) cancer. A query come across the reliability of conclusions from retrospective databases regarding the clinical significance of this grade combination without slide re-review.