Wu ZY, Kim HJ, Lee JW, et al. - The locoregional recurrence (LRR) rate for cases with pure ductal carcinoma in situ (DCIS) who underwent nipple-sparing mastectomy (NSM) followed by immediate breast reconstruction without adjuvant radiotherapy were determined. In addition, potential risk factors for LRR and/or nipple-areola complex recurrence (NR) were investigated. Researchers performed a retrospective chart review for 199 consecutive cases with pure DCIS who underwent NSM and immediate breast reconstruction between March 2003 and December 2015. They identified the LRR rate of 4.5% and the NR rate of 3% at 10 years. High nuclear grade, negative receptor status, positive human epidermal growth factor receptor 2 (HER2) status, and negative hormone receptor/positive HER2 subtype were correlated with heightened risk for NR in the univariate analysis. Negative progesterone receptor status was noted to be an independent risk factor for LRR in the multivariate analysis. Findings suggest the possible feasibility of NSM as a surgical option even for DCIS with a tumor-to-nipple distance of 1 cm or less if the retroareolar resection margin is negative for malignancy. Patients at high risk for recurrence could be recognized via determining the molecular subtype of DCIS.