Cosgrave D, Vencken S, Galligan M, et al. - Among patients listed for major open hepatopancreaticobiliary surgery and who were receiving 10 μg.kg⁻¹ intrathecal morphine, researchers undertook this analysis to investigate if a reduced incidence of respiratory depression without an increase in pain scores could be achieved with a postoperative low-dose naloxone infusion, given intrathecal morphine is related to a risk of respiratory depression. The participants were randomly assigned to receive a postoperative infusion of naloxone 5 μg.kg⁻¹.h⁻¹ (naloxone group) or saline at an identical infusion rate (control group) until the morning post-surgery. According to the findings, a reduced incidence of respiratory depression after intrathecal morphine treatment was brought about by a low-dose naloxone infusion in patients undergoing major hepatopancreaticobiliary surgery at the expense of a small rise in postoperative pain.