The association between fasting blood glucose trajectory and cancer risk in Chinese population without diabetes

International Journal of Cancer Jan 12, 2020

Feng X, Wang G, Lyu Z, et al. – Via performing a study involving 69,742 participants without diabetes who were selected from the Kailuan cohort, researchers assessed the links between fasting blood glucose (FBG) trajectories, the alterations in FBG over time, and the risk of cancer, especially for gastrointestinal cancer. Using group-based trajectory modeling, they modeled FBG trajectories (2006-2010) and defined five trajectories: low-increasing (n = 6,275), moderate-stable (n = 44,120), moderate-increasing (n = 10,149), elevated-decreasing (n = 5,244), and elevated-stable (n = 3,954). Compared with the moderate-stable group, the estimated HR for overall cancer was higher in the low-increasing group and was higher for gastrointestinal cancer in the elevated-stable group. For both overall cancer and gastrointestinal cancer, a positive link with the low-increasing group was evident among individuals with an initial BMI ≥ 25 kg/m2, and a positive link with the elevated-stable group was identified among participants with a stable BMI. Among participants without diabetes, there was a link between FBG trajectories and cancer risk. Furthermore, the researchers suggested that BMI may alter these associations.

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