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The relationship of breast density in mammography and magnetic resonance imaging in women with triple negative breast cancer

European Journal of Radiology Jan 12, 2020

Mema E, Schnabel F, Chun J, et al. - The institutional Breast Cancer Database was queried to recognize the clinicopathologic and imaging features in females undergone mammography and breast MRI between 2010-2018. Investigators sought to assess the relationship between mammographic density, background parenchymal enhancement and fibroglandular tissue on MRI in women with triple-negative breast cancer (TNBC) contrasted to women with non-triple negative breast cancer (non-TNBC). In a total of 2,995 women, 225 had TNBC with a median age of 60 years and a median follow-up of 5.69 years. TNBC was correlated with African-American race 36/225, BRCA1,2 positivity 34/225, past history of breast cancer 35/225, showing on breast exam 126/225 or MRI 13/225, palpability 133/225, more invasive ductal carcinoma (IDC) 208/225, higher stage (stage III) 37/225, higher grade (grade 3) 186/225, lower mammographic breast density (MBD) 18/225, lower fibroglandular tissue (FGT) 17/225, and lower background parenchymal enhancement (BPE) 89/225 in comparison with women non-TNBC. It was found that the greater proportion of females with lower MBD, FGT, and BPE in women with TNBC implies that MBD, amount of FGT and degree of BPE might be correlated with breast cancer risk in females with TNBC.
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