Gupta I, Freid B, Masarapu V, et al. - Experts conducted IRB-approved research comprising 55 individuals in order to evaluate the PCa detection rates of contrast-enhanced, transrectal subharmonic ultrasound imaging (SHI). Initial 5 individuals were analyzed for SHI optimization, while the left 50 were assessed with contrast-enhanced sonography using continuous SHI, color, and power Doppler, as well as conventional grayscale, unbroken color, and power Doppler and SHI, linked with maximum flash replenishment. Among 50 individuals, cancer was discovered in 22. The majority of people identified by SHI demonstrated notable PCa such as SHI remained an autonomous marker of malignancy in a multivariate logistic regression model. In this first-in-humans research, a preliminary estimation of the diagnostic efficiency of SHI for the detection of clinically notable PCa (up to 80%) was presented.