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Cumulative use of therapeutic bladder anticholinergics and the risk of dementia in patients with lower urinary tract symptoms: A nationwide 12-year cohort study

BMC Geriatrics Jan 08, 2020

Wang YC, Chen YL, Huang CC, et al. - Researchers examined the link between anticholinergic use and dementia among patients exhibiting lower urinary tract symptoms (LUTS). Participants were patients aged 50 years and over with newly diagnosed LUTS. Based on their cumulative defined daily doses (cDDDs) of anticholinergics, the participants were grouped into four categories: < 28 cDDDs, 28–84 cDDDs, 85–336 cDDDs, ≥337 cDDDs. A follow-up until dementia development or until the end of 2012 was performed. The recruitment of 16,412 patients was done. Findings revealed an increased risk of incident dementia in relation to higher cumulative anticholinergic exposure in patients with LUTS aged 50 years of age and over. This risk rose with either the use of one anticholinergic agent or switching anticholinergic agents cumulatively. Clinically, reviewing and weighing the therapeutic risks and advantages of using anticholinergics in LUTS treatment was recommended.
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