Katagiri R, Song M, Zhang X, et al. - Using three prospective cohorts, researchers examined colorectal cancer risk in relation to dietary consumption of branched-chain amino acids (BCAAs). In this first prospective study to address this topic, they analyzed the Nurses' Health Study I [(NHS), number of participants (n) at baseline = 77,017], NHS II (n = 92,984), and the Health Professionals Follow-up Study [(HPFS) n = 47,255] cohorts. The participants were evaluated every 4 years by administering validated food frequency questionnaires, and follow-up questionnaires on lifestyle were answered biennially. They used Cox proportional hazards regression models to compute hazard ratios and 95% confidence intervals. A weak inverse link between BCAA consumption and colorectal cancer was found in multivariable adjusted models. However, there was no link between BCAA consumption and colorectal cancer risk when dairy calcium was incorporated into the models. Overall, no evidence demonstrated a link between higher dietary BCAA consumption and a higher risk of colorectal cancer.