Loukogeorgakis SP, Burnand K, MacDonald A, et al. - In this single-centre study (2011-2017) involving 61 individuals (41 male, of whom 7 circumcised at presentation), researchers sought to establish independent risk factors that may predict symptomatic persistence of vesico-ureteral reflux (VUR). For this investigation, they involved consecutive prospectively-collected patients with primary VUR on voiding cystourethrogram. Data reported that VUR was diagnosed in 37 patients after prenatal hydronephrosis investigation and in 22 patients after febrile UTI. The analysis was performed using data from a total of 77 refluxing renal units (RU). Renal scarring VUR patients were three times more likely to develop UTI breakthrough. According to findings, renal scarring is the most significant risk factor in primary VUR patients for breakthrough UTI and could be used to assess those at risk of progression of symptomatic VUR.