• Profile

RNA expression profiling of lymphoepithelioma-like carcinoma of the bladder reveals a basal-like molecular subtype

American Journal of Pathology Dec 19, 2019

Manocha U, Kardos J, Selitsky S, et al. - Investigators identified 16 cases of lymphoepithelioma-like carcinoma of the bladder (LELC-B) at Johns Hopkins University and conducted RNA sequencing on fourteen cases to understand the underlying biology of LELC-B and to molecularly describe through RNA expression profiling as well as immunohistochemistry. The study demonstrated that analogous to basal tumors, LELC-B tumors were enhanced in a basal-like molecular subtype and shared a high level of immune infiltration and programmed cell death ligand 1 expression. Therefore, in this rare disease, the basal-like phenotype was constant with the known sensitivity of LELC-B to chemotherapy and proposed that immune checkpoint therapy shall be examined.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen