Hochfelder CG, et al. - Among patients with locoregionally advanced hypopharyngeal cancer, researchers explored the connection between modality of primary treatment and survival. In the registry of Surveillance, Epidemiology and End Results (SEER) (years 2004–2015), 2,328 adult patients were diagnosed with stage III or IV, M0, hypopharyngeal squamous cell carcinoma. They compared individuals who received primary chemoradiation (CRT) to those who received surgery with either adjuvant radiation therapy (S + RT), or surgery with adjuvant CRT (S + CRT). In addition, the latter primary surgery group (S + Adj) was analyzed collectively. According to this retrospective cohort study, S + Adj had higher-grade cancers and more advanced T staging. Treatment with S + Adj was related to longer DSS and OS vs those treated with primary CRT among individuals with advanced hypopharyngeal cancer reported in the SEER database.