Effectiveness of influenza vaccination among older adults across kidney function: Pooled analysis of 2005-2006 through 2014-2015 influenza seasons

American Journal of Kidney Diseases Dec 15, 2019

Ishigami J, et al. – Via performing an observational cohort study, researchers determined the efficacy of influenza vaccination in older adults with and without reduced kidney function. They analyzed 454,634 person-seasons in 110,968 people 65 years or older in the Geisinger Health System between the 2005 and 2015 influenza seasons, with baseline features matched between those with and without vaccination employing inverse probability weighting. To estimate adjusted ORs, they performed a pooled logistic regression analysis. The prevalence of influenza vaccination was reported to be 63.3% in the 2014-2015 influenza season, without obvious variation across estimated glomerular filtration rate (eGFR) categories. In lower eGFRs, a higher incidence of hospitalization was noted. Findings revealed the link of influenza vaccination with a lower risk for hospitalizations with pneumonia/influenza and major cardiac diseases in eGFR ≥ 30 mL/min/1.73 m2.

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