Suwal B, et al. - Researchers examined the significance of spectral domain optical coherence tomography (OCT) changes on visual outcome and persistence of subretinal fluid (SRF) in patients with idiopathic central serous chorioretinopathy (CSCR). They conducted a retrospective study in 48 eyes of 45 patients diagnosed as CSCR; fundus photography, spectral-domain OCT, and fluorescein angiography were undertaken in all eyes in selected cases. At presentation, 22.91% of the cases had retinal pigment epithelium detachment. Improvement in the logMar best-corrected visual acuity was observed; it improved from 0.46±0.29 at presentation to 0.18±0.22 at 3 months. The mean foveal thickness was 486.81±146.06 μm and 259±94.5 μm at presentation and 3 months, respectively (paired T-test). Poor visual outcome (BCVA > 0.3 logMar) was observed in correlation to following OCT factors: disruption in the inner segment (IS)/outer segment (OS) junction or external limiting membrane (ELM) line and hyper-reflective dots in the intra/subretinal layer (Fischer’s Exact test). SRF persistence was noted in 26 of 48 eyes at 3 months. The persistence of SRF was identified in correlation with the following two OCT factors (Pearson’s Chi-square test): the presence of discontinuation in IS/OS junction and hyper-reflective dots in the intra/subretinal layer. These findings suggest the value of early morphologic changes in OCT for predicting visual outcome and persistence of subretinal fluid at 3 months.