Dutkiewicz R, et al. - Given high mortality is experienced following an acute hip fracture (AHF) surgery and retrospective studies suggest that mortality in AHF-patients can be predicted by cognitive impairment and/or altered levels of Alzheimer Disease (AD)-biomarkers, researchers investigated if this is true or not, by performing this prospective single-center study with 373 AHF-patients, operated in spinal anesthesia. They assessed cognitive status by clinical dementia rating. Findings revealed that increased mortality in patients with an AHF could be predicted by cognitive impairment and altered CSF biomarker levels suggestive of AD pathology, and so seemingly even prior to clinical dementia diagnosis by early biomarker analysis; this notion may improve perioperative treatment and postoperative rehabilitation and therefore may have substantial clinical implications.