Zhou Q, Wu X, Liu Y, et al. - Asthenozoospermic patients were classified into the AS group, curcumin treatment group and brusatol + curcumin treatment group in order to assess the protective mechanisms of curcumin against oxidative stress in asthenozoospermic people. As the results exhibited, in comparison with spermatozoa of AS group, treatment with curcumin significantly reduced reactive oxygen species formation and malondialdehyde production, nonetheless, nuclear factor erythroid 2-related factor (Nrf2) expression and sperm function were inhibited by Brusatol and Nrf2 inhibitor. Data imply that through monitoring Nrf2 level, curcumin might shield spermatozoa.