Wood JJ, Kendall PC, Wood KS, et al. - Researchers investigated how cognitive-behavioral therapy (CBT) affects anxiety symptoms in children with autism spectrum disorder (ASD) and maladaptive and interfering anxiety. They conducted a randomized clinical trial including 167 children with ASD and maladaptive and interfering anxiety at 3 universities in US cities. In this trial, the children were randomized to receive standard-of-practice CBT, CBT adapted for ASD, or treatment as usual. Relative to children receiving standard-of-practice CBT and treatment as usual, significantly lower anxiety scores were evident among those receiving cognitive behavioral therapy designed for these children. Both types of CBT produced higher rates of positive treatment response than treatment as usual. This analysis thereby supports the efficacy of CBT in treating maladaptive and interfering anxiety in children with ASD.