Chaaban MR, et al. - Utilizing the Clinformatics database from 2015 to 2017, researchers, for the first time, used ICD-10 CM codes to study the trends of biphasic and recurrent anaphylaxis in all patient care settings (inpatient, outpatient, emergency department, and observation). Recurrent anaphylactic events occurring within 1 year after the initial event was the main outcome measure. There were a total of 19,039 patients with incident anaphylaxis in 2016 and in the 12-month period after the index date, 2,017 had a recurrent anaphylaxis case. Venom followed by food allergens was the most common trigger for recurrent anaphylaxis. In the first 3 days after the initial event, in younger patients (< 18 years), and in patients with allergic rhinitis and/or asthma, recurrent anaphylaxis is more common. Doctors must prescribe auto-injectors of epinephrine and warn their patients about the possibility of recurrence.