• Profile

Influence of variation in global sperm DNA methylation level on the expression level of protamine genes and human semen parameters

Andrologia Dec 04, 2019

Laqqan M, et al. - Totalling 200 semen samples were obtained from men (50 proved fertile, 60 normospermia and 90 oligospermia) in order to assess whether there was a difference in the status of global DNA methylation among the study groups and to evaluate their influence on the protamine expression level and human semen parameters. Among the study groups, a notable variation was observed in the global sperm DNA methylation and the protamine 1 and protamine 2 expression level. In the oligospermia group vs the proved fertile group with fold change, down-regulation was noted in the protamine 1 and protamine 2 expression levels. Thus, this study suggested that the modification in global DNA methylation may affect the protamine expression level and could result in abnormalities in human semen parameters.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen