Cui L, He T, Jiang Y, et al. – Researchers developed a micro-simulation Markov model to determine FRAX-based fracture probabilities—specifically, osteoporosis states and relevant morbidities, including hip fracture, vertebral fracture, and wrist fracture—in Mainland China using real-world data, at which intervention could be cost-efficient. When the 10-year probability of major osteoporotic fracture on the basis of FRAX was >7%, treatment with zoledronate was cost-efficient. The FRAX threshold grew by age from 51 to 65 years old, and reduced in elder age groups, varying from 4% to 9%. In all, the extensive use of zoledronate was of both clinical and economic advantages among Chinese postmenopausal women. Moreover, using a FRAX-based intervention threshold of 7% with zoledronate should permit cost-efficient access to therapy to individuals, and contribute to decreasing the disease burden of osteoporosis in Mainland China.