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Predictors of poor response and adverse events following botulinum toxin-A for refractory idiopathic overactive bladder

Urology Nov 28, 2019

Abrar M, et al. - Seventy-four individuals who received botulinum toxin-A (BTX-A) injections for the first time between the dates of March 2004-August 2017 were examined in this single-center study in order to determine whether a poor response and adverse events (voiding dysfunction and urinary tract infection) were predictable for first time BTX-A injections in an individual cohort of refractory idiopathic overactive bladder with detrusor overactivity. Male gender was related to a poor response to BTX-A injections and heightened risk of clean intermittent self-catheterization (CISC). Lower maximum urinary flow rates and women with hysterectomies were at heightened risk of needing CISC postinjection. Moreover, performing CISC was related to an enhanced risk of UTI. Thus, these factors could be important when counseling or choosing people.
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