MacGowan RJ, Chavez PR, Borkowf CB, et al. - In this randomized clinical trial involving 2,665 candidates, researchers analyzed the impact of providing HIV self-tests on the frequency of testing, diagnoses of HIV infection, and sexual risk behaviors. On request, all candidates had access to online web-based HIV testing resources and telephone counseling. During the trial, more self-testing (ST) participants reported testing 3 or more times than control participants. During the trial, the cumulative number of newly identified infections was double as high in the ST participants as the control participants, with the largest difference in HIV infections identified in the first 3 months. Among social network members who used the self-tests, the ST participants reported 34 newly identified infections. Distribution of HIV self-tests offers a useful mechanism for raising awareness of HIV infection and preventing men who have sex with men transmission.