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A comparison of two LDL cholesterol targets after ischemic stroke

New England Journal of Medicine Nov 25, 2019

Amarenco P, Kim JS, Labreuche J, et al. - In this parallel-group trial carried out in France and South Korea, researchers randomized 2,860 individuals with ischemic stroke in the former 3 months or a transient ischemic attack (TIA) within the former 15 days to a target LDL cholesterol level of less than 70 mg per deciliter (lower-target group, n = 1,430) or to a target range of 90 mg to 110 mg per deciliter (higher-target group, n = 1,430) in order to examine the target level for LDL cholesterol to decrease cardiovascular events following stroke. It was concluded that following an ischemic stroke or TIA with evidence of atherosclerosis, compared with those who had a target range of 90 mg to 110 mg per deciliter, individuals who had a target LDL cholesterol level of less than 70 mg per deciliter had a lower risk of succeeding cardiovascular events.
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