Heisser T, et al. - In this systematic review and meta-analysis of all available studies evaluating the outcome of a follow-up colonoscopy among individuals at average risk for colorectal cancer with a negative former colonoscopy (no adenomas), experts analysed and reviewed the evidence on the predominance of colorectal adenomas and cancers at a follow-up screening colonoscopy following negative index colonoscopy, stratified by interval between examinations and by gender. A total of 28 studies were recognized, comprising of 22 cohort studies, five cross-sectional studies, and one case-control study. However, in more than 20% of individuals within five years of a negative screening colonoscopy identification of any neoplasms was noted, the discovery of advanced neoplasms within 10 years was exceptional. Findings imply that 10-year intervals for colonoscopy screening following a negative colonoscopy, as currently suggested, could be sufficient, although more studies are required to establish the empirical support for appropriate recommendations and to examine even longer intervals.