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RNA expression profiling of lymphoepithelioma-like carcinoma of the bladder reveals a basal-like molecular subtype

American Journal of Pathology Nov 18, 2019

Manocha U, Kardos J, Selitsky S, et al. - Sixteen cases of lymphoepithelioma-like carcinoma of the bladder (LELC-B, a rare subtype of urothelial carcinoma comprising of undifferentiated epithelial cells within a dense inflammatory cell infiltrate) were recognized at Johns Hopkins University and RNA sequencing was performed on 14 in order to molecularly identify LELC-B through RNA expression profiling and immunohistochemistry to learn its underlying biology. The study showed that comparable to basal tumors, LELC-B tumors are enriched in a basal-like molecular subtype and partake a high level of immune infiltration and PD-L1 expression. Moreover, the basal-like phenotype is constant with the observed sensitivity of LELC-B to chemotherapy and proposes that immune checkpoint therapy should be investigated in this rare disease.
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