• Profile

ARCHES: A randomized, phase III study of androgen deprivation therapy with enzalutamide or placebo in men with metastatic hormone-sensitive prostate cancer

Journal of Clinical Oncology Nov 19, 2019

Armstrong AJ, Szmulewitz RZ, Petrylak DP, et al. - Researchers performed a multinational, double-blind, phase III trial, the ARCHES, to test enzalutamide (a potent androgen-receptor inhibitor) with respect to its efficacy and safety in metastatic hormone-sensitive prostate cancer (mHSPC). They randomly allocated (1:1) 1,150 men with mHSPC to enzalutamide (160 mg/day) or placebo, plus androgen deprivation therapy (ADT), stratified by disease volume and previous docetaxel chemotherapy. Findings revealed that a significant reduction in the risk of metastatic progression or death over time was achieved with enzalutamide plus ADT vs placebo plus ADT treatment in men with mHSPC, including those with low-volume disease and/or previous docetaxel. The safety analysis, performed in this study, appeared consistent with the safety profile displayed by enzalutamide in earlier clinical trials in castration-resistant prostate cancer.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen