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Testosterone therapy and venous thromboembolism risk in men with and without hypogonadism

JAMA Nov 18, 2019

Walker RF, Zakai NA, MacLehose RF, et al. - In men with and without evidence of hypogonadism, researchers ascertained if short-term testosterone therapy exposure was correlated with increased short-term risk of venous thromboembolism (VTE). They observed an association between the use of testosterone therapy in the 6-month case period and an increased risk of VTE among men with and without hypogonadism in this case-crossover study comparing 6-month testosterone use for 39,622 men who had a VTE with testosterone use 6-12 months before the VTE. Such findings suggest that when prescribing testosterone therapy, caution should be used.

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