Hudgins JD, et al. - Given the leading causative role of prescription opioid misuse in unintentional injury and death among adolescents and young adults, researchers sought to estimate the past-year prevalence of prescription opioid use and misuse, sources of prescription opioids, and additional substance use among adolescents and young adults. In this retrospective analysis of the National Survey on Drug Use and Health for the years 2015 and 2016, inclusion of 27,857 adolescents (12–17 years of age) and 28,213 young adults (18–25 years of age), corresponding to 119.3 million individuals in the extrapolated national population, was performed. The use of prescription opioids in the previous year was reported in 27.5% of respondents, corresponding to an estimated 32.8 million individuals, including 21.0% of adolescents and 32.2% of young adults. Among adolescents and young adults, opioid misuse was reported in 3.8% and 7.8%, respectively. Opioids are obtained for free from a friend or relative or from a single prescriber by most individuals misusing prescription opioids. A high prevalence of use of other substances, including cocaine, hallucinogens, heroin, and inhalants was reported in individuals with prescription opioid misuse.