Kowalewski KF, Hendrie JD, Nickel F, et al. - A total of 3,427 studies, of which eleven were eligible for qualitative and ten for quantitative analysis reporting on 3,664 persons, were identified in this systematic review and meta-analysis order to systematically investigate the influence of prophylactic abdominal or retroperitoneal drain placement or omission in uro-oncologic surgery. Six studies discussed radical prostatectomy (RP), four studies partial nephrectomy (PN) and one study radical cystectomy. For RP a decrease in postoperative complications was discovered without drainage, whereas no distinctions for re-intervention, hematoma were noted. partial nephrectomy, for overall complications or re-intervention, no variations were discovered. For RC, no variations for all parameters were identified. The overall quality of evidence was evaluated as low. Hence, for standardized RP and PN cases, the omission of drains could be suggested. Nevertheless, divergences from the standard could still mandate the placement of a drain and continue to be surgeon preference. For RC, limited evidence to suggest the omission of drains was there and prospective research should concentrate on this matter.