• Profile

Variations in testosterone pathway genes and susceptibility to testicular cancer in Norwegian men

International Journal of Andrology Nov 01, 2019

Kristiansen W, et al. - Given testicular cancer (TC) risk may be assumingly influenced by imbalance between the oestrogen and androgen levels in utero, and therefore, there may be a possible contribution of variation in genes implicated in the action of sex hormones to the variability of an individual’s susceptibility to TC, researchers determined polymorphisms in the luteinizing hormone receptor (LHR), 5α-reductase II and androgen receptor genes as well as their likely connection with TC in this case-control study involving 651 TC cases and 313 controls in a Norwegian population. On comparing genotypes between all TC cases and controls, they found a statistical significant variation in patients being heterozygous for the LHR Asn312Ser polymorphism. The histological subtypes seminoma and non-seminoma demonstrated no statistically significant difference. Overall, a possible link between genetic variation in the LHR gene and the risk of developing TC was indicated.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen