Diabetes is associated with increased risk of hepatocellular carcinoma in patients with cirrhosis from nonalcoholic fatty liver disease

Hepatology Nov 01, 2019

Yang JD, Ahmed F, Mara KC, et al. - Using Cox proportional hazard analysis, researchers explored the connection between diabetes and hepatocellular carcinoma (HCC) in patients with nonalcoholic steatohepatitis (NASH) cirrhosis in an expanded NASH cirrhosis cohort with a longer follow-up. In addition, they analyzed the link between other metabolic risk factors (BMI, hypertension, and hyperlipidemia) and HCC. Between January 2006 and December 2015, all patients with the diagnosis of NASH cirrhosis seen at Mayo Clinic Rochester were identified. Utilizing the United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation registry for external validation, all adult liver transplant registrants with NASH between 2004 and 2017 were identified. Of the 354 patients (mean age at cirrhosis evaluation was 62) with NASH cirrhosis at the Mayo Clinic, 253 suffered from diabetes and 145 were male. Thirty patients developed HCC during a median follow-up of 47 months. In patients with NASH cirrhosis, diabetes is related to an increased risk of HCC. Moreover, in multivariable analysis, age and low serum albumin were significantly linked to a heightened risk of developing HCC. Other metabolic risk factors, including BMI, hyperlipidemia, and hypertension, were not related to HCC risk.
Go to Original

Sign-up to continue reading. It is free & takes less than 2 mins

  • 45 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Free & unlimited access to original articles and quizzes
  • Nonloggedinlock icon
    Secure: we never sell your data
This article is only available to members. Are you a doctor? Click here to signup for free.
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay