Cil G, et al. - Researchers used longitudinal cohort design to estimate the link between prescription drugs for pain and for sleep and incident frailty risks in older US adults examined in the Health and Retirement Study. This inquiry was performed on community-living respondents who were aged 65 years and older, excluding people who received recent treatment for cancer (N = 14,208). Overall 7,201 respondents were included in the longitudinal analysis, who had no frailty at baseline and had at least one follow-up wave with complete data on both prescription drug use and frailty, or date of death. For pain only, for sleep only, and for both indications, the proportions endorsing prescription drug use were estimated to be 22.1%, 6.8%, and 7.7%, respectively. The burden frailty model prevalence was estimated to be 41.0% and significantly differed by drug use. Findings revealed a significant association of prescription pain and sleep drug use with increased incidence of frailty.