Self-reported incident hypertension and long-term kidney function in living kidney donors compared with healthy nondonors
Clinical Journal of the American Society of Nephrology Oct 12, 2019
Holscher CM, Haugen CE, Jackson KR, et al. - By comparing living kidney donors (n = 1,295) with a weighted cohort of 8,233 healthy nondonors, researchers examined the link between living kidney donation, hypertension, and long-term eGFR. They used a parametric survival model to quantify the risk of self-reported hypertension. They focused on the link between hypertension and the annual shift in eGFR, by using multilevel linear regression and clustering by participant, with an interaction term for race. Findings revealed a higher risk of hypertension in kidney donors vs similar healthy nondonors, irrespective of race. A plateau in the usual post-donation increase of eGFR was seen in donors who developed hypertension.
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