Periyasamy S, John S, Padmavati R, et al. - In this genome-wide association study (GWAS) that involved a sample of Indian afflicted individuals (n = 1,321), family members (n = 885), and unrelated cases and controls (n = 886), researchers identified and functionally assessed genetic loci for schizophrenia in a GWAS of a unique Indian population. Through bioinformatic analyses and cellular and zebrafish gene expression studies, NAPRT1 (nicotinate phosphoribosyltransferase gene) was found out to be a novel susceptibility gene. These conclusions insinuate that the rs10866912 genotype and niacin status may have suggestions for schizophrenia susceptibility and treatment, provided this role of the gene in niacin metabolism and the evidence for niacin deficiency aggravating schizophrenia-like symptoms in neuropsychiatric diseases such as pellagra and Hartnup disease.