Fowler III AA, Truwit JD, Hite RD, et al. - In this double-blind, placebo-controlled, multicenter trial conducted in 7 medical intensive care units in the United States, that involved 167 individuals in the ICU, researchers ascertained the impact of intravenous vitamin C infusion on organ failure scores and biological markers of inflammation and vascular injury in individuals with sepsis and acute respiratory distress syndrome (ARDS). In the primary endpoints of variance in mean modified Sequential Organ Failure Assessment score from baseline to 96 hours or in C-reactive protein levels and thrombomodulin levels at 168 hours, no notable variations between the vitamin C and placebo groups were noted. Hence, in this preliminary study, a 96-hour infusion of vitamin C, in comparison with the placebo, did not considerably enhance organ dysfunction scores or modify markers of inflammation and vascular injury in individuals with sepsis and ARDS. In order to assess the possible role of vitamin C for other outcomes in sepsis and ARDS, additional research is required.