Wang W, Zhang Y, Wang R, et al. - In this community-based study, researchers examined risk factors as well as epigenetic markers for predicting left ventricular diastolic dysfunction with preserved ejection fraction (LVDD-PEF) among 1,568 residents (over 65 years) in Shanghai, People’s Republic of China. They made a diagnosis of LVDD-PEF by performing echocardiography on the participants. The potential epigenetic markers that contributed to LVDD-PEF were identified via DNA methylation by whole-genome bisulfite sequencing. According to the findings, the factors that independently predicted LVDD-PEF in the community-dwelling elderly population were female, BMI, pulse pressure, and carotid intima-media thickness. A possible important role of DNA methylation regulation for LVDD-PEF was also suggested.