Dovc K, Piona C, Mutlu GY, et al. - In young adults with type 1 diabetes (T1D), researchers tested the safety and effectiveness of day-and-night fully closed-loop insulin therapy using faster (Faster-CL) vs standard insulin aspart (Standard-CL). Twenty candidates with T1D on insulin pump therapy had two 27-h inpatient periods with unannounced afternoon moderate-vigorous exercise and unannounced/uncovered meals. Faster-CL and Standard-CL were compared in random order. According to this double-blind, randomized, crossover trial, the proportion of TIR was comparable for both arms: 53.3% (83% overnight) in Faster-CL and 57.9% (88% overnight) in Standard-CL arm. For both groups, the proportion of time in hypoglycemia < 70 mg/dL was 0.0%. Using either faster or standard insulin aspart, fully closed-loop insulin delivery was safe and efficient in obtaining near-normal glucose concentrations outside postprandial periods. The closed-loop algorithm has been better adjusted to the standard insulin aspart. There have been no serious adverse events.