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Extremes of age decrease survival in adults after lung transplant

Chest Sep 13, 2019

Lehr CJ, et al. - Using data from the Scientific Registry of Transplant Recipients, researchers examined 14,253 recipients of lung transplant (aged ≥ 18 years of age) to estimate survival and to determine risk factors for death because age has been cited as a factor in the plateau of long-term survival following lung transplant. They analyzed age as both a continuous and categorical variable (age < 30, 30-55, and > 55 years). At all time-points after transplant, age was identified as the most significant risk factor for death and with increases in time from transplant, its effect became more prominent. Extremes of age, higher creatinine, single lung transplant, hospitalization before transplant, and increased bilirubin were all identified as risk factors for death for all patients. Differences were noted in risk factors for death across ages, and survival for those in the youngest age category was disproportionately influenced by social determinants of health. Via divergent pathways, the lowest posttransplant survival was felt by the youngest and oldest adult recipients.
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