Brent DA, et al. - Via a pharmacoepidemiologic study done from January 1, 2010, to December 31, 2016, researchers investigated the possible relationship between parental use of prescription opioids and the rising rate of youth suicide. A total of 148,395 and 184,142 children had parents who did not use opioids and children with parents who did use opioids, respectively. There were 100,899 children aged 10 to 14 years and 47,496 children aged 15 to 19 years with parents who did not use opioids and 96,975 children aged 10 to 14 years and 87,163 children aged 15 to 19 years with parents who did consume opioids. Of , A total of 212 of the children with parents who did not use opioids, attempted suicide and of the children with parents who did use opioids, 678 attempted suicide. Parental use of opioids was related to a doubling of the risk of a suicide attempt by their offspring. The correlation continued to be important following adjusting for child age and gender, addition of child and parental depression and diagnoses of substance use disorder, and addition of parental history of suicide attempts. Geographical differences in opioid use did not alter the correlation. Thus, children of parents who use prescription opioids are at progressed risk for suicide attempts, which could be a giving factor to the time trend in adolescent suicidality. The care of families with a parent who consumes opioids should involve mental health screening of their children.