Berrondo C, et al. - A total of 543 patients aged 18 years who were undergoing hernia/hydrocele repair or orchiopexy by a pediatric urologist prior to and following the introduction of chlorhexidine gluconate (CHG) were recruited in this study by the researchers in order to explain the proportion of pediatric patients undergoing hernia/hydrocele repair or orchiopexy who develop a postoperative (postop) surgical site infections (SSI), to ascertain whether preoperative CHG baths/wipes were correlated with SSI, to recognize other factors related to SSI, and to estimate the cost of CHG baths/wipes in this population. Patients were randomized in the no CHG group (n = 203) and in the CHG group (n = 340). Of SSI, the overall rate was 0.92%. No correlation between the use of CHG and SSI was noted. No patient or peri-operative factors were related to the development of SSI. No CHG-related adverse events were observed. In 2018 US dollars, the cost of materials was estimated at $3.29/patient. In conclusion of this first study to assess the use of preoperative antisepsis with CHG baths/wipes in an exclusively pediatric population, CHG baths/wipes add cost with no clear advantage for decreasing SSI in pediatric patients who were undergoing hernia/hydrocele repair or orchiopexy.