McDonald EG, et al. - Via a time-series analysis of a move from a 417-bed hospital with ward-type rooms to a 350-bed facility with solely private rooms in Montréal, Canada, experts investigated whether single-patient rooms were related to reduced rates of common multidrug-resistant organism transmissions and healthcare-associated infections. In comparison with the 27 months before, during the 36 months following the hospital move, an immediate and sustained reduction in nosocomial vancomycin-resistant Enterococcus (VRE) colonization and methicillin-resistant Staphylococcus aureus (MRSA) colonization was observed, as well as VRE infection. Rates of Clostridium difficile infection (CDI) and MRSA infection did not decline. Thus, the move to a new hospital with exclusively single-patient rooms seemed to be related to a sustained reduction in the rates of new MRSA and VRE colonization and VRE infection; nevertheless, the move was not correlated with a decrease in CDI or MRSA infection. Moreover, these conclusions may have significant implications for the role of hospital construction in expediting infection control.