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Total motile sperm count trend over time: Evaluation of semen analyses from 119,972 men from subfertile couples

Urology Aug 25, 2019

Tiegs AW, et al. - Researchers examined whether the total motile sperm count (TMSC) show clinically-relevant change over time within the subfertile population. They evaluated 119,972 first semen analysis of men presenting to selected infertility centers in 2 countries between 2002 and 2017 and categorized the semen analyses into 3 clinically-relevant groups based on treatment options: TMSC > 15 million (M) (Group 1), in which no insemination intervention would be required; TMSC 5-15 M (Group 2), in which intrauterine insemination would be appropriate; and TMSC of < 5 M (Group 3), in which in vitro fertilization would be considered. Outcomes revealed a decline in the proportion of men with normozoospermia and an increase in men at risk of requiring fertility treatment over the study time period. With each year of advancing paternal age, they noted a decline in TMSC by 1.1 percentage points.
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