Playford MP, Dey AK, Zierold C, et al. - Researchers compared serum 1,25-dihydroxyvitaminD (1,25(OH)₂D) with serum 25-hydroxyvitamin D with regard to performance in capturing cardiovascular risk in psoriasis. At baseline, FDG PET/CT and CCTA scans were performed in 122 consecutive psoriasis patients in order to measure visceral adipose volume, aortic vascular uptake of FDG, and coronary plaque burden respectively. The psoriasis cohort was middle-aged, mostly male, and Caucasian. Participants had moderate-to-severe skin disease. At baseline, biologic psoriasis therapy for skin disease management was being taken by almost one quarter of the cohort. Findings revealed the association of low 1,25(OH)₂D levels with visceral adipose volume, vascular uptake of FDG, and coronary plaque burden independent of conventional risk factors—suggesting that the cardiometabolic risk related to vitamin D deficient states may be better captured by 1,25(OH)₂D.