Liu AW, Song SO, Hayashi T, et al. - In this prospective study that included 297 diabetes-free Japanese-Americans with 10 years of follow-up, researchers explored the longitudinal connection between the change in body composition, directly measured by CT and future insulin sensitivity. By HOMA-IR and the Matsuda index, insulin sensitivity was calculated. During follow-up, the baseline and intra-abdominal fat area change were significantly and independently linked to changes in the HOMA-IR and Matsuda index. No significant associations were observed in multivariate analyses between thigh subcutaneous fat area (SCFA) and insulin sensitivity or abdominal SCFA and HOMA-IR, but an increase in abdominal SCFA was linked with reduced insulin sensitivity measured by the Matsuda index. According to findings, a boost in visceral adiposity predicted diminished insulin sensitivity over 10 years of follow-up independent of the size of this adipose depot at baseline.