Haller F, Skálová A, Ihrler S, et al. - Researchers performed this study to assess the utility of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) immunostaining and NR4A3 fluorescence in situ hybridization in the differential diagnosis of acinic cell carcinoma (AciCC). They compared a total of 64 AciCCs including 17% cases with high-grade transformation, 29 secretory (mammary analog) carcinomas (MASC), and 70 other salivary gland carcinomas. Outcomes revealed a high specificity and sensitivity of NR4A3 immunostaining as a marker for AciCC. This may be particularly relevant in cases with high-grade transformation and in “zymogen granule”-poor examples within the differential diagnostic spectrum of AciCC and MASC.