Zhu k, et al. – Using data obtained via health record linkage, researchers determined the dose-response relationships between baseline plasma 25-hydroxyvitamin D (25OHD) with hip DXA BMD at year 1, lumbar spine BMD, and trabecular bone score at year 5, and fracture-related hospitalizations over 14.5 years. This secondary analysis included data from 1,348 women aged 70-85 years at baseline (1998) from the Perth Longitudinal Study of Aging in Women. The investigators found that 27.6% of women experienced any fracture-related hospitalization, and 10.6% experienced hip fracture-related hospitalization. Penalized spline regression models displayed a decline in risk with increased 25OHD levels up to 65 nmol/L and 75 nmol/L for hip fracture and any fracture-related hospitalization, respectively. Overall, the authors noted that 25OHD levels > 50 nmol/L are a minimum public health target, and 25OHD levels beyond 75 nmol/L might not have an additional benefit to decrease fracture risk in older white women.