Association of intensive vs standard blood pressure control with cerebral white matter lesions

JAMA Aug 17, 2019

The SPRINT MIND Investigators for the SPRINT Research Group - Via performing a sub-study of a randomized clinical trial that included 449 hypertensive individuals with longitudinal brain MRI, researchers assessed the correlation of intensive blood pressure treatment with cerebral white matter lesion and brain volumes. Mean white matter lesion volume progressed from 4.57 to 5.49 cm3 vs a rise from 4.40 to 5.85 cm3 in the standard treatment group. Mean total brain volume reduced from 1,134.5 to 1,104.0 cm3 in the intensive treatment group vs a drop from 1,134.0 to 1,107.1 cm3 in the standard treatment group. Hence, among hypertensive adults, targeting a systolic blood pressure of < 120 mmHg vs < 140 mm Hg was significantly related to a smaller increase in cerebral white matter lesion volume and a higher reduction in total brain volume; however, the variations were small.

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