Lee MW, et al. - In patients with high myopia, researchers determined longitudinal changes of the ganglion cell-inner plexiform layer (GC-IPL) thickness. Study participants were divided into two groups: a high myopia group (axial length ≥ 26.0 mm) and a normal control group. Based on age (decade), both groups were divided into subgroups: 20s, 30s, 40s and 50s. In each subgroup, 20 eyes were included. In high myopia and control groups, the average GC-IPL thickness at the first visit was 78.50 ± 8.79 µm and 84.29 ± 6.12 µm, respectively. The average GC-IPL thickness showed a significant change over time in both groups. Data reported that GC-IPL reduction rates for people aged in their 50s, 40s, 30s and 20s with high myopia were −0.81 µm/year,–0.51 µm/year, −0.28 µm/year and −0.12 µm/year, respectively, and in controls in their 50s, 40s, 30s and 20s, they were −0.31 µm/year,–0.25 µm/year, −0.12 µm/year and −0.02 µm/year, respectively. In addition, there was a statistically significant interaction between group and duration among people aged 50 years. According to this prospective observational study, highly myopic eyes had thinner GC-IPL and a significantly higher GC-IPL reduction over 3 years vs normal eyes. In addition, in elderly individuals in both groups, the decrease rate of the GC-IPL thickness was higher, which was more prominent in the high myopia group.